I use this as replacement on the bridge pickup of a two humbucker Tele.
In contrast to other DiMarzios which seem to focus or boost on specific frequency ranges, this sounds evenly spread from bass to treble. Overall it sounds similar to what you get on a 70s PAF style pickup with a little more output. This is not a hot pickup, so if you are looking for high gain and modern metal this probably isn't for you. But it is a good all-round replacement pickup and great for rock and classic metal tones.